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Rifampin Fact Sheet


PDF Version for this Fact Sheet

Rifampin is an antibiotic

Rifampin is an antibiotic medicine that is often used to prevent meningitis (infection of the covering of the brain and spinal cord) or other infections caused by the bacterium Neisseria meningitidis (meningococcus) and by Haemophilus influenzae type b (Hib). Rifampin is recommended for people who have had close contact with people known to have these diseases. It is also effective against some other bacterial infections.

Certain people should not take rifampin

  • People who have had a reaction to rifampin in the past
  • Pregnant or nursing women
  • People with a history of liver or kidney disease

Rifampin has some side effects

  • Urine, stool, saliva, sputum, sweat, and tears may temporarily turn red or orange in color. Soft contact lenses may be permanently stained. Soft contact lenses should not be worn until 48 hours after treatment is completed.
  • Birth control pills may not prevent pregnancy when taking rifampin. Use an extra form of birth control during that monthly cycle.
  • Stomach aches, vomiting, diarrhea, headaches, dizziness, or pain in the arms and legs can occur while taking rifampin. These symptoms will go away when you stop taking the medicine.

Follow instructions carefully for taking rifampin

Your doctor or the health department will tell you if you need to take rifampin. They will also tell you when to take it, how much to take, and how long to take it. Call your doctor or health department if you have any questions.


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Maryland Department of Health & Mental Hygiene
— Epidemiology & Disease Control Program

May 2002

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